発表論文
2024
（プレスリリース）
膵癌術後の再発リスクを早期に予測し術後の生存率向上へ
（原著論文）
膵癌術後の再発リスクを早期に予測し術後の生存率向上へ
（原著論文）
Prognosis prediction of PDAC via detection of O-glycan altered extracellular vesicles in perioperative sera.
Uemura S, Kabe Y, Kitago M, Matsuda S, Abe Y, Hasegawa Y, Hori S, Tanaka M, Nakano Y, Sato Y, Itonaga M, Ono M, Kawakami T, Suematsu M, Kitagawa Y.
Cancer Sci. 2024 Sep 16. doi: 10.1111/cas.16341. Online ahead of print.
PMID: 39285510
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
Yamamoto T, Hayashida T, Masugi Y, Oshikawa K, Hayakawa N, Itoh M, Nishime C, Suzuki M, Nagayama A, Kawai Y, Hishiki T, Matsuura T, Naito Y, Kubo A, Yamamoto A, Yoshioka Y, Kurahori T, Nagasaka M, Takizawa M, Takano N, Kawakami K, Sakamoto M, Wakui M, Yamamoto T, Kitagawa Y, Kabe Y, Horisawa K, Suzuki A, Matsumoto M, Suematsu M.
Cancer Res. 2024 Apr 1;84(7):1065-1083. doi: 10.1158/0008-5472.CAN-23-2266.
PMID: 38383964
2023
（原著論文）
Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s.
Irie M, Kabata H, Sasahara K, Kurihara M, Shirasaki Y, Kamatani T, Baba R, Matsusaka M, Koga S, Masaki K, Miyata J, Araki Y, Kikawada T, Kabe Y, Suematsu M, Yamagishi M, Uemura S, Moro K, Fukunaga K.
Cell Rep. 2023 Jun 27;42(6):112610. doi: 10.1016/j.celrep.2023.112610. Epub 2023 Jun 7.
PMID: 37294636
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H.
Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017.
PMID: 37267913
Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide.
Nakamura T, Honda S, Ito S, Mizoguchi T, Yamamoto T, Kasahara M, Kabe Y, Matsuo K, Suematsu M.
J Bone Miner Metab. 2023 Jul;41(4):470-480. doi: 10.1007/s00774-023-01425-y. Epub 2023 Apr 10.
PMID: 37036533
The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia.
Yamazaki H, Uehara M, Yoshikawa N, Kuribara-Souta A, Yamamoto M, Hirakawa Y, Kabe Y, Suematsu M, Tanaka H.
JCI Insight. 2023 Apr 24;8(8):e162382. doi: 10.1172/jci.insight.162382.
PMID: 36917179
Polysulfide Serves as a Hallmark of Desmoplastic Reaction to Differentially Diagnose Ductal Carcinoma In Situ and Invasive Breast Cancer by SERS Imaging.
Kubo A, Masugi Y, Hase T, Nagashima K, Kawai Y, Takizawa M, Hishiki T, Shiota M, Wakui M, Kitagawa Y, Kabe Y, Sakamoto M, Yachie A, Hayashida T, Suematsu M.
Antioxidants (Basel). 2023 Jan 20;12(2):240. doi: 10.3390/antiox12020240.
PMID: 36829799
2022
（原著論文）
Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19.
Abe K, Kabe Y, Uchiyama S, Iwasaki YW, Ishizu H, Uwamino Y, Takenouchi T, Uno S, Ishii M, Maruno T, Noda M, Murata M, Hasegawa N, Saya H, Kitagawa Y, Fukunaga K, Amagai M, Siomi H, Suematsu M, Kosaki K; Keio Donner Project.
Sci Rep. 2022 Jan 25;12(1):1299. doi: 10.1038/s41598-022-05424-3.
PMID: 35079088
2021
（原著論文）
Possible Therapeutic Strategy Involving the Purine Synthesis Pathway Regulated by ITK in Tongue Squamous Cell Carcinoma.
Onidani K, Miura N, Sugiura Y, Abe Y, Watabe Y, Kakuya T, Mori T, Yoshimoto S, Adachi J, Kiyoi T, Kabe Y, Suematsu M, Tomonaga T, Shibahara T, Honda K.
Cancers (Basel). 2021 Jul 2;13(13):3333. doi: 10.3390/cancers13133333.
Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1.
Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1.
Kabe Y, Koike I, Yamamoto T, Hirai M, Kanai A, Furuhata R, Tsugawa H, Harada E, Sugase K, Hanadate K, Yoshikawa N, Hayashi H, Noda M, Uchiyama S, Yamazaki H, Tanaka H, Kobayashi T, Handa H, Suematsu M.
Cancers (Basel). 2021 Jun 29;13(13):3265. doi: 10.3390/cancers13133265.
PMID: 34209885 Free
PMID: 34283052
On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity.
Honda K, Hishiki T, Yamamoto S, Yamamoto T, Miura N, Kubo A, Itoh M, Chen WY, Takano M, Yoshikawa T, Kasamatsu T, Sonoda S, Yoshizawa H, Nakamura S, Itai Y, Shiota M, Koike D, Naya M, Hayakawa N, Naito Y, Matsuura T, Iwaisako K, Masui T, Uemoto S, Nagashima K, Hashimoto Y, Sakuma T, Matsubara O, Huang W, Ida T, Akaike T, Masugi Y, Sakamoto M, Kato T, Ino Y, Yoshida H, Tsuda H, Hiraoka N, Kabe Y, Suematsu M.
Redox Biol. 2021 May;41:101926. doi: 10.1016/j.redox.2021.101926. Epub 2021 Mar 2.
PMID: 33752108
2020
（原著論文）
Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection.
Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection.
Tsugawa H, Kabe Y, Kanai A, Sugiura Y, Hida S, Taniguchi S, Takahashi T, Matsui H, Yasukawa Z, Itou H, Takubo K, Suzuki H, Honda K, Handa H, Suematsu M.
PLoS Biol. 2020 Sep 29;18(9):e3000813. doi: 10.1371/journal.pbio.3000813. eCollection 2020 Sep.
PMID: 32991574
Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.
Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.
Furuhata R, Kabe Y, Kanai A, Sugiura Y, Tsugawa H, Sugiyama E, Hirai M, Yamamoto T, Koike I, Yoshikawa N, Tanaka H, Koseki M, Nakae J, Matsumoto M, Nakamura M, Suematsu M.
Commun Biol. 2020 Sep 4;3(1):479. doi: 10.1038/s42003-020-01202-x.
PMID: 32887925
O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer.
Yokose T, Kabe Y, Matsuda A, Kitago M, Matsuda S, Hirai M, Nakagawa T, Masugi Y, Hishiki T, Nakamura Y, Shinoda M, Yagi H, Abe Y, Oshima G, Hori S, Nakano Y, Honda K, Kashiro A, Morizane C, Nara S, Kikuchi S, Shibahara T, Itonaga M, Ono M, Minegishi N, Koshiba S, Yamamoto M, Kuno A, Handa H, Sakamoto M, Suematsu M, Kitagawa Y.
Cancers (Basel). 2020 Aug 31;12(9):2469. doi: 10.3390/cancers12092469.
PMID: 32878320
Comparative Glycomic Analysis of Exosome Subpopulations Derived from Pancreatic Cancer Cell Lines.
Comparative Glycomic Analysis of Exosome Subpopulations Derived from Pancreatic Cancer Cell Lines.
Matsuda A, Kuno A, Yoshida M, Wagatsuma T, Sato T, Miyagishi M, Zhao J, Suematsu M, Kabe Y, Narimatsu H.
J Proteome Res. 2020 Jun 5;19(6):2516-2524. doi: 10.1021/acs.jproteome.0c00200. Epub 2020 May 6.
PMID: 32338917
Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites.
Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites.
Kabe Y, Takemoto D, Kanai A, Hirai M, Ono Y, Akazawa S, Horikawa M, Kitagawa Y, Handa H, Rogi T, Shibata H, Suematsu M.
NPJ Sci Food. 2020 Feb 20;4:4. doi: 10.1038/s41538-020-0064-6. eCollection 2020.
PMID: 32133417
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